Weir was introduced to guitar and piano by his mother when he was a child. His father is New Zealand broadcaster Dick Weir, who introduced young Barnaby to broadcast radio by taking him into Radio New Zealand every weekend. Weir considers this experience pivotal to his story.

Born in 1978, Weir started his professional music career in the nineties playing with The Black Seeds and Dub Connection. At this time he also worked in the creative and ad production department at Radio Active 88.6 FM and hosted the Roots & Culture specialist dub/reggae show on the same station.

Since he co-founded The Black Seeds in 1998, the band has recorded five studio albums, a live album, an EP, two remix albums and 11 singles. They have also toured New Zealand, Australia, America, Europe and the Pacific.

In 2002, Weir released his debut Flash Harry album on Capital Recordings. In 2003 they also released the debut Dub Connection 12-inch record and a split Flash Harry vs. The Video Kid 12-inch.

Since Weir co-founded Fly My Pretties in 2004, they have released three albums and extensively toured New Zealand and Australia. 

In 2006 Weir was part of the Bacardi B-Live OE: Brazil project, which saw him and several other New Zealand musicians travel to Sao Paolo in Brazil to record a collaborative album and later on tour it through New Zealand.

In 2011, Weir released his first album under his own name, Tarot Card Rock. The album was released by EMI New Zealand.

In 2012, Weir was briefly hospitalised after contracting myocarditis, a virus that attacks the heart.

Between his collaborative projects and solo projects, Weir has toured with, played alongside, or opened for Roots Manuva, John Browns Body, Horace Andy, Katchafire, Ladi6, Fat Freddy's Drop, The Nudge, King Kapisi, Salmonella Dub, Shapeshifter and Anika Moa.

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